Having the Lizard in an earlier draft of the script didn't mean Ock got lumbered with some of his character just because Lizard was removed. The Vulture was in the early drafts of the Spider-Man 3 script. It doesn't mean Venom got his characterization just because he was excised in favor of Venom.
The wife was included as part of the parallel between Peter and Octavius. Otto had the life Peter had wanted for himself. Great scientist, and married to the woman he loves. They even touched on this in the comics. Otto used to be in love and engaged to a woman called
Mary Alice (wink wink Otto's version of Mary Jane) until he lost her because of his biotch of an interfering mother.
In the movie Ock's wife dies before he even becomes a villain, much like how he lost Mary Alice before he became Doc Ock. Very different to Curt Connors' wife who lives when her husband becomes a villain, and along with their son is a key factor in the Lizard's story because he's a father and husband who is endangering his family, and has someone at home worrying about him and needing him to be saved from himself. Ock didn't have any of this. Ock's motivation wasn't to cure his body of some ailment. Ock wasn't friends or a mentor to Peter. That's why I say any similarity he had with Lizard was superficial.
It's like saying Electro, Sandman, Rhino etc are all the same because they're losers who are thieves and got their powers by accident.
I'd like to see some official source that says this is what they did. Then I'll concede to it. Otherwise it's just putting two and two together and getting five.
Which is exactly how it usually goes between them. Ock has his own plans and goals that don't involve Spider-Man, and Spider-Man gets in the way of them all the time. Ock did hate Spider-Man in the movie for getting in his way, and tried to kill him several times. But the difference was in spite of his interference he didn't stop Ock from getting what he was after. Ock still got away with the money from the bank. He still got the tritium. He still rebuilt his reactor. In the comics the only reason Ock formed the Sinister Six was because he got to the point where he was sick of Spider-Man messing up his schemes, and felt it was time he and the other villains got rid of a common problem they all had.
Unlike the Goblin, who has a specific fixation on Spider-Man.
As we've already established, Ock was not given Connors characterization or motivation. They were totally different in that regard. What you are correct about is doing a more ruthless version of Ock. One who becomes the Master Planner/gang war/ Sinister Six leader type of villain. That will help separate him from Molina's Ock.