Peter is popular once more, the town loves him and he's getting really good at heroing. He has a girlfriend and everything in life is going his way. But then it all goes to hell. Norman uses a serum developed by him and Otto a long time ago to create a soldier with the power of a tank. Flint Marko and Alex O'Hirn are two test subjects. Hirn being slightly more...easy to manipulate is the subject for the serum. Marko feels left out but Norman has a job for him. Meanwhile O'Hirn undergoes his transformation and becomes the Rhino.
Meanwhile Peter is chilling at home working on his webshooters and see's a metero go by his window. He follows and goes through into a park down the block where he see's the meteor empty. He looks around and shrugs taking a picture for the Bugle just incase, not seeing the alien symbiote attaching itself to his shoe.
Marko is arrested and sent into prison where he meets up with the prisoners Otto, Adrian, Quentin, Kraven and talks to them about Normans offer. They all except to destroy Spider-Man. At that moment Marko takes out a small signal device from his mouth and it activates. At that moment Alex busts through the prison walls as the Rhino and Marko is shocked. As is everyone but he is friendly and wants them to cause chaos. And the prisoners do. The 7 escape with Flint helping Otto carry his life support machine in the chaos, to Oscorp secret level.
Norman is waiting with all their various weaponry and tools. He welcomes them to the 6. In the morning Peter wakes up and puts on his suit. It's a weekend so he goes on patrol but as he swings the symbiote covers his suit turning it black. Peter is shocked but feels...better in the black suit. He realizes it must be from the meteor. He stops a criminal robbing a bank. Flint Marko and beats him down till he's bloody embarrassing him and leaving him hanging froma lampost wedgie style. Much to the shock of some people and humor of others.
Peter swings away but then he's knocked down by Shockers blasts, Rhino runs up to him and Peter, never having seen him panics and dodges as Rhino flips the car like a desk. Peter looks around as Doc Ock, Shocker, Kraven, Mysterio, Rhino, and Vulture all show up and Spidey isn't sure what too do. But he's faced big battles before he can face this, especially with the suit. He refers to himself as we saying "we can do this". At first it's weird but it doesn't matter. Ock introduces them as the Sinister Six and a battle begins.
A long epic battle that takes span over the place of a few minutes that I can't even begin to describe, but do to intelligence and his symbiote power up. Peter provials. The last villain he beats on is Rhino for a while, Rhino may be bigger, but Peter is stronger now, he stops as Rhino is done now. Almost dead, actually. Peter swings off and realizes that the suitis changing him, but maybe it's for the better, the world needs "us" serious heroes as he refers to himself in plural again.
Webbing home at night, Goblin attacks, with the 6 failed he tries to beat Peter himself. Peter and Goblin go at it for a while, but despite Goblin being physically stronger than regualr Peter the symbiote made Peter more brutal and powerful. He beats down Norman ripping his Glider in two and using a blade about to impale him but stops himself. as he drops it the ring hurts Peter. While peter struggles Norman escapes stating he doesn't need to beat Peter, Peter is beating himself.
Peter fights against and removes the symbiote later and begins recovering from the damage it did to him and his life.
-Other Happenings in the film include Peter being a jerk to Brock and his boss Jonah. He is fired and his girlfriend breaks up with him in a heated argument. All thats left is his Aunt, the symbiote takes over Brock in the end and Venom is born. And Marko comes to Osborn in private begging for powers to humiliate Spider-Man as well.