I'd be happy to--and remember, this is just a theory of mine based on anecdotal evidence. In an interview Steve Wacker gave to IGN in promotion for Brand New Day, there was an exchange about what role some of the more the classic supporting characters would have in the new status quo:
http://comics.ign.com/articles/840/840731p3.html
Second, look at Hobie Brown's current status: he's no longer the Prowler now, essentially forced to retire because of injuries and the Superhero Registration Act, so he's currently in character limbo. Plus, he's a C-lister, yet at the same time important enough to Spidey's history for his death to resonate--especially since Spidey considers him a really good friend who has helped him out so many times in the past.
Also, we know that Menace, according to solicits for next issue and the Spider-Man bible that got leaked, is going to kill someone. Aside from the fact that he seems to have connections with the Green Goblin which has always been personal to Peter, if Menace kills Hobie Brown, one of the few people Spidey could call a trusted friend, then that makes it all the more personal. Plus, it provides that much more pressure for Jackpot, who is hunting him down herself already, to bring him to justice because Menace is now targeting people who are registered under the act, which would suggest that Menace has inside knowledge and is therefore that more dangerous. It also makes Harry the prime suspect because not only because his father is not only the Green Goblin and therefore allowing his son to have access to Goblin weaponry, but also because Norman is the head of the Thunderbolts and would have access to files on heroes or retired heroes who registered under the act. Finally, since Spidey and Jackpot are on opposite sides of the law thanks to registration and each have their own motives for wanting bringing down Menace, it makes their partnership (plus the fact that, as we assume, Jackpot is Mary Jane, his "ex-girlfriend") have that much more internal conflict. That's what I'm going on anyway.