In the cinematic universe, Wade Wilson is a mutant with super-agility and reflexes by default.
That is the Wade from Origins. In Deadpool 2016, Wade as same as Vanessa and Angel Dust are not referred as mutants. Negasonic and Colossus may be the only mutants. In the cinematic universe, we found 2 characterizations of Jubilee, Emma, and Deadpool.
Cyclops, Jean, and Storm? No. They don't have the same X1-3 story, or it's altered, but considering they are in the DoFP ending scene, they are not gone forever.
They are alive in 2023 new timeline, those from OT are gone forever like Angel X3.
Sorry, but Cycclops, Jean, Storm, Angel, Kurt, ... are in the same case. 1973 is altered, Scott and Jean are going to be recruited by Xavier, Kurt rescued by Mystique, Angel and Storm recruited by Apocalypse. X1-X2-X3 are deleted from continuity
At last, new timeline : Scott Jean Storm Nightcrawler Angel in Apocalypse, Scott Jean Storm in DOFP ending scene
original timeline : Scott Jean Storm from trilogy, Kurt X2 and Angel X3. All dead before 2023
Warren was not in his 40s in the original timeline. He was born in the 80s
Forget "10 years ago" during opening scene. Such as Jean in her chilhood, "20 years ago" must be forgotten, as we know X3 set in 2006. 1986 is improbable, because she cant be younger than her 1983'version