And I do hope they have two villains, namely Electro and Goblin, Emma Stone has been very vocal about doing the death of Gwen, and with recent rumour that Shailene Woodley will have a small role as MJ in this film compared to the third where she will be the lead alongside Garfield, I think we just might see Gwen die in this film.
As for Venom, definietly think they should introduce the symbiote in this film... I don't think they will have it bond with Peter, as they might not want to repeat that story arc yet again. So this time, they can simply have Osborn develop it. That is where Peter got his Spider powers, its also where Connors was developing his regenerating tissue cells or whatever that turned him into Lizard. So why not just have them be the ones that create the Symbiote from the same Spiders that made Spidey and combine it with a revised version of Connors "lizard" formula? Eddie Brock should be more like the earth 616 Brock, and maybe his just really broke and unlucky when he sees a ad on the net, to make easy money, by being a test subject or whatever. They test the symbiote on him, it bonds with him, and he escapes.