I think Jones would have good instict for the character. This is from an interview he did regarding the bits of humor in Source Code:
".....I think humor is a huge tool, an incredibly useful tool to get the audience to form an attachment with these characters. If your main character and your audience are both laughing about the same thing—you know, if there's comedy and it's shared—I think it helps the audience bond with the protagonist."
This could certainly apply to Spidey for some scenes, no? He can certainly develop rich characters and pathos as well as handle the action and humor (as seen in Source Code).
I'm not saying I think Sony could get him (who knows), just that this is the type of guy they should aim for if Webb doesn't return.