MCU must introduce solo movies of let's say Gambit, Storm, Cyclops, Cable, Xavier, Magneto, Jean, Iceman, Beast, Nightcrawler, Archangel, Rogue, Colossus, Forge, Kitty, Jubilee, Bishop, Mystique, Psylocke, Emma Frost etc. first before releasing an X-Men film. I imagine 4 or 5 movies in my mind before an X-Men movie. Otherwise it will be an eventual failure again because of Wolverine. They will depend on Wolverine again and when there's no Wolverine they will fail. Eventually Wolverine himself will start to fail because of character fatigue and indirectly X-Men will fail again regardless of Wolverine's presence or not. So, solo movies before an X-Men movie is very important to make audiences to care about other characters.
As for Wolverine and Deadpool, they'll continue to make a lot of money. As long as Marvel doesn't put himself in a position where they can't release a succesful X-Men film without Wolverine, everything should be fine.