So what kind of personality changes would people be okay with some of the B-list villains, just because a lot of B-list Spidey villains usually have no personality beyond genetic gimmick based super villain:
I suggested Mysterio be far more cruel and sadistic then his rather generic comic book counterpart (there have stories like Guardian Devil that play up a more psychopathic Mysterio, its sad one of Mysterio's best showings happened in a Daredevil story rather then a Spidey story). To me when people say they are sick of sympathetic villains and want a unsympathetic villain who is just a bank robbing jerk, it seems like they don't want a truly unsympathetic villain, if you don't want a sympathetic villain, then I say give me a truly unsympathetic villain, not a slightly unpleasant bank robbing jerk.
Someone like Shocker could made more noble and moral, a criminal for sure, but one with standards and limits and someone who would object to working for a truly evil boss who has no standards or limits, you could really contrast Shocker and Mysterio in a story.