What I didn't like? There's a laundry list of problems in my view:
1. Spider-Man's quips just weren't funny, and all of it felt very, VERY forced. I'm sorry but when you're fighting for your life and possibly facing being beaten to death I doubt your mind is would be registering what your next one-liner is going to be.
In the comics Spidey would normally be joking around those he had a clear advantage over or if the fight/opponent wasn't posing an immediate threat to his life. Even the car thief scene just wasn't funny and the only real one-liner I recall from the school fight was, "Bad, bad, Lizard?"
I tell that to my dog virtually every day, heck, if that's all the creative humor a screenwriter needs I might get hired for the sequel.
2. The editing/pacing was just atrocious. I can barely remember what movie might have been more poorly edited than this one, but I can't; scenes were just chopped to pieces and the transitions were my no means smooth. Scenes that should have been given their time were incredibly rushed and those scenes that I cared less about seemed to drag on forever.
3. The subway fight; that earned a big WTH?! The choreography of it was horrid. Honestly, the acquiring of his powers were completely out of order; I mean, I would have preferred it if he had just gone home feeling incredibly ill, woken up the next morning and things just started happening like his strength manifesting the way it did.
If I recall correctly his spider-sense was one of the last things to manifest itself in the comics, not the first.
4. Really, he let a group of common thugs chase him? If that scene had been anywhere close to accurate he would have just stood his ground and and disposed of all of them in seconds without breaking a sweat.
Ordinary humans should not have seemingly posed a threat to him at all; also when he shows up at night with bruises and a bloody eye, what was that caused by, a normal right cross from some perp?
Please, his durability, or lack thereof was a big disappointment for me.
5. Uncle Ben's death...honestly Andrew's acting was, wow, real awkward to watch. I mean, what was that noise he kept making in between each "Oh, god" a shriek or a yelp?
There was just no emotional weight to that scene whatsoever, helped in part to some very questionable acting in my opinion.
6. His temporary mask, yeah, there was a lot of nervous laughter from the audience when he first showed up wearing that thing; yeah, he would have been better off with a cheap, run of the mill ski mask then that thing.
7. The lizard's face/head; yeah, it didn't carry any intimidation and, holy crap, to watch him talk while he was in the form was just so strange looking.
Hell the 90's cartoon portrayed a better Lizard/Spidey confrontation in 20 minutes than this entire movie did.
In my opinion, when it comes to the origin story; Raimi's original is head and shoulders above this. I'd put the ASM on par with Spider-Man 3 but in no way does it belong in the same dimension as the original two.