I know a lot of people (myself included) see Danny and Misty as one of the classic comic pairings. I rank it up there with Ollie and Dinah, Lois and Clark, Pete and MJ - but if you go back and read the really early appearances for Iron Fist (Marvel Premier to early Iron Fist v1 issues), there's a strong (well, as strong as comic writing from the mid-to-late seventies can be, with regards to relationships) attraction between Colleen and Danny.
That Changes in the early issues of IF, when there's a plot device situation which, arguably, makes their connections stronger. But also changes it.
Also, Danny and Misty did not get along all that well when they first met. He was an arrogant (yet strangely self conscious), humorless ass who literally abandoned his adopted home so he could seek revenge on the man who was responsible for the death of his parents.
Only to punk out at the last minute when faced with a cripple. And yes, the 'punk out' bit was said sarcastically. it was Danny's first, defining heroic moment.
Misty was an Ex-Cop turned bionically enhanced private detective who pretty much thought Danny was an arrogant, humorless ass. She didn't really know about the self-conscious part.
With Misty still being a cop at the end of LC, I imagine they're having to change the pairing and dynamic on several levels. She and Colleen, for example.
I don't recall how many episodes Simone is supposed to be in IF (if at all, someone correct me on this, please) - but I can see an episode or two going a long way to establishing a strong dynamic. It's easy to say that she and Colleen know one another, but the partnership hasn't start, etc.