Not really. Jason Todd being The Joker could change their relationship in more than just one way. It would depend on the mind behind the creative process. You might have one idea about it, that you wrongly think of as being the only possible one, but maybe the person writing the script has 2 or 3 more ideas that you haven't even thought of. Who knows?
As far as the level of interest of their relationship, that's highly debatable. Plenty of people could possibly enjoy something that you wouldn't. I don't mind change as long as it is well executed. Without change, without experimental artists, we wouldn't have some of the greatest movies and comic books of all time. Being an artist is also about being able to explore new grounds instead of being afraid of it, like most are nowadays.
That being said, i'm not saying that i would love Jason Todd to be Joker. I don't even think that would happen. I'm just not being square-minded about it. I'm accepting the fact that we don't know how good it could turn out to be until we actually see it. I've read enough comic books to know that sometimes the most unexpected ideas can turn out to be great.