The first Morlun story and the whole Ezekiel arc WERE VERY GOOD. In fact that entire sequence (JMS's whole run with JRjr) would be classic, if he had not made the terrible The Other. Which sullies this idea even more.
But I mean c'mon. Right now I really would like to see Lizard mixed with Kraven's Last Hunt. That could be a great movie. And tie in well with Pete/MJ.
After that...I don't know. After 4, MJ and Peter and going to reach a stability that will make more movies harder and then villains will just become the focus which I don't want. If we ARE going to take any ideas from recent Spidey stories, I say GG's return and masterminding of much of Parker's woe (responsible for the movie symbiote? Pushing Harry with "hallucinations?" who knows).
But Morlun? REALLY? No.