I think that's precisely why it's not going to do much better than Ant-Man or any other lower-tier grossing MCU film. This film is being promoted on "it's a woman, it's a woman, it's a woman, RAWR, we're so progressive!!" and I think that's going to turn off more fans than the studio realizes. People want to see movies that entertain them, not films that preach to them. If the film is insulting its audience, word will spread like wildfire.
Re: women being 52% of the movie going public. Fine and dandy, but are they 52% of the comic book genre fandom? I'd bet my bottom dollar most of that money is still coming from the male audience. I mean Hell, the Twilight movies made a buttload of money but that money came almost entirely from a female audience because it was the sort of film that on average, women tend to prefer (a love story).