Yeah i see most of the show being set within a spaceship actually, and don't really see that as a problem.
Flying and constructs both can work on a tv budget. constructs would have to be slightly powered down, but I think that would be acceptable. Given the budget of any of the shows I mentioned, I'm sure a GL could do great things..
It would be obvious to everyone that certain scenes and plot lines would come about so that costs can be cut, but no one would mind if the writing and acting was good.
It'd be ambitious and expensive, but I really think it could be done.