Yeh, if I was parker Id consider doin myself in to prevent any more dangerous supervillains from emerging. There's clearly some dark, dangerous probability field hovering around him... or mary jane.
This sounds like blackcat territory.
Anyway, if we'll be seeing the lizard... then they're gonna have to have a sewer scene. I always liked seeing spidey crawling upside down through some dirty tunnel muttering to himself... 'You dont ever see the fantastic four in the sewers... or the avengers! never have I seen the avengers in a sewer... well maybe the hulk.'
I like that balance of everyman and super-human
I was just watching that episode yesterday!

You're exactly right man, it's an exquisite thing about Spider-man. The Lizard is a GREAT villain because of the position he puts Spidey in not only in his life, having to figure out how to stop his extremely powerful and uncontrollable mutated friend from doing horrible things, but also the position of his image as a superhero. He's not the Fantastic Four, he has to crawl through murky sewers pursuing freaks of nature that he knows he probably can't handle.. And, naturally, that provides him the opportunity to do some Spidey-esque mumbling (which he hasn't done enough of in the movies if you ask me).

t:
Also, the way you said 'looks like Black Cat territory'.. I was gonna say 'Kraven the Hunter'.

I think that the Lizard is the best film chance for Kraven, period - apart from possibly the Man-Spider... - and it would create more depth and suspense around the chase to save Connors, the stress of having to do it before someone else takes him out.
This isn't the thread for it, but you're right about something else too, Cat CERTAINLY has the stage open to her for the reason you described, but only if they tie up MJ and Gwen's love interest roles as a result of what happened in Spider-man 3... I think there's enormous potential for all three of these charaters in the next movie. It would be
really refreshing for a new storyline like that, and the appropriate next step for Spidey after all the hell he'd unleashed under the influence of the Symbiote. Seriously, the situation with MJ is just MORBID now, I easily see her caving in and giving up on trying to be with Peter. Cat, on the other hand, is much better suited to his life as Spidey.. and what comes with it.