Well, the stuff Dan Slott hinted in
his interview with Comic Book Resources and in the one he gave at Newsarama regarding "the lasting effects on Spider-Man, the cast, and the rest of the Marvel Universe," the "heart breaking" developments, and "the lasting effects," I'm guessing the following possible developments which I'm sure somebody will tell me I'm wrong, wrong, wrong.
*After teaming-up with Miquel O'Hara to save Tiberius Stone, SpOck double-crosses him and kills Stone, believing it's the "responsible" thing to do in order to prevent him from founding Alchemex. This, of course, results in the 2099 timeline being erased from existence. However, due to some "whibly-wobbly, timey-whimy," Miquel O'Hara is able to survive being erased himself and winds up stuck in the present day with no way of getting back home to his original time. This, of course, allows for the possibility of a new
Spider-Man 2099 series should Marvel choose to have one.
*SpOck, on the verge of completing his doctorate as Peter, goes to Max Modell and reveals that he secretly purchased the majority of the Horizon Labs stock, thus making him the actual owner of Horizon Labs. And as his first act, he fires Modell from his own company and makes himself the new CEO and relocates the headquarters of Horizon Labs to "Spider-Island II."
*Upon encountering the Black Cat, SpOck, because he no longer has Peter's memories, will treat her just like any other criminal, and thus she will feel betrayed that "her Spider" now "hates" her so much, probably blaming herself for "driving him away."
*In Superior Spider-Man #21, SpOck battles with his ex-girlfriend, Stunner, who, seeks revenge against "Spider-Man" for killing her beloved. However, since the real Stunner is in a coma, this Stunner is really a "virtual-reality ghost" of who she once was. Thus, after defeating her, SpOck is forced to remove Stunner from life-support to prevent future "ghosts" from emerging.
*SpOck proposes...to Anna Maria Marconi, much to the shock of Aunt May, as she was not expecting her "nephew's new fiancee" to be a little person. This, along with SpOck taking over Horizon Labs the way he did, begins to wonder if something is seriously wrong with "Peter." Likewise, when Mary Jane hears the news, it convinces her even more that something more is going on besides "Peter" acting like a different person, becoming even more determined to try and get in touch with Carlie to find out what is really going on.
*Considering that Flash was the guy who always rooted for Spidey no matter what, and who, in spite of not knowing that Spidey was really "Puny Parker," had a better, instinctive grasp of what was really going on with Spidey than most of the other cast members, I imagine that during or after his encounter with SpOck, Flash is going to say something to someone along the lines of, "I don't who that is or how it happened, but I'm telling you--
that's not the real Spider-Man!" And of course, no one will believe him.
*Carlie, after conducting the autopsy on Alistair Smythe, finds that there is a recording of SpOck's confession, thus giving her the evidence she needs. Unfortunately for her, SpOck gets wind of this via his spider-bots, and has his minions go after her, resulting in the death of Captain Watanabee, and Carlie framed for her murder and thus becomes a fugitive.
*Harry Osborn and his son are kidnapped by members of the Goblin Cult and brought back to New York to the Green Goblin, or rather the Goblin King, who tells Harry that he needs his help in stopping Spider-Man. Believing that the Goblin King is his father, Norman, Harry outright refuses, saying how he's done nothing but ruin his life and wants nothing more to do with him. The Goblin King then says "I didn't want to have to do this, but you leave me no other choice." He then removes his mask to reveal the face of...PETER PARKER!
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