Well Cal has been in the place for awhile (days, weeks maybe). It's possible that he didn't originally know that his wife was alive, but that they just reunited offscreen. Admittedly it'd be more interesting if he did know all along (and having such an emotional moment happen and then NOT showing it would be really lame imo). As for his "revenge on Whitehall" obsession, well I think that the whole "you tortured and mutilated my wife" thing would be incentive enough for him to go after Whitehall, even if she survived. It must have still been an agonizing experience for her, and she apparently has permanent scars as a result of what Dr. Nazi did.