He has actually battled the Hulk quite a bit in the comics: In Hulk #208-209, #347-348, #457, Hulk Annual #18. He also was in the Hulk Classics line as one of the figures:
And he was also in the Hulk-related wave of Marvel Legends as well (where the BAF was Fin Fang Foom):
I tend to think of him as a Thor, Avengers and Hulk villain. He has actually fought others too though such as Spider-Man (while he was teamed up with Titania) and also She-Hulk (again teamed with Titania), as well as Hank Pym.
EDIT: Apparently he has battled SHIELD as well, specifically Maria Hill, Sharon Carter and Victoria Hand, and was defeated by them. It's a shame that Victoria is dead now, because we've had all 3 of those in the MCU and they could easily have teamed up again and recreated that story. I guess this means that Creel can be defeated just by the Agents of SHIELD cast.