Voted for Depp.
Quirky and strange characters are his forte so a character called 'Doctor Strange' seems almost perfect and fated.
Before his star went astronomical with Jack Sparrow, Depp had carved out a nice little niche for himself as a versatile character actor known for picking non-comercial projects that interested him.
I think a lot of people have forgotten that because of the over saturation caused by POTC's 1,2 and 3.
I perosnally think Depp would be awesome in this role - and his known wouldnt look out of place alongside Norton and Downey Jnr etc.
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Not to mention the fact that the guy was seemingly born with the perfect facial hair for Strange.t:
This here is a much debated topic between me and some friends. My choice for the good doctor is Mark Strong. Put a fancy cape on that guy and he's ready to go.
http://l.yimg.com/img.omg.yahoo.com/omg/us/img/c1/d8/7415_11949891446.jpg
Quinto is not a bad suggestion...
But I am leaning toward Joseph Fiennes:
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Or Jim Caviezel:
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the ninth gate being one of my favorite depp movies, that being said, after seeing it in theaters years ago I said to myself leaving the theater....depp is doctor strange. that was 7-8 years ago. it's a no brainer, that picture above says it all. nobody can pull of that look more than depp can. seriously, it's like doctor strange leaped from his comic book pages to do the ninth gate.