Agent Thermal said:
Who do you guys feel the Lizard SHOULD be paired with in a movie, if anyone at all?

Like I've stated before, I personally want Mysterio (the psychological threat) and the Lizard (the physical threat) as the pair of villains in one of these sequels - for some "can't put my finger on it" reason, Harry/Green-Goblin and the Lizard together just doesn't sit well with me...
Oh well, that's just my opinion. Yours?

Who do YOU guys feel would "compliment" the Lizard best in a movie, or would a storyline with JUST the Lizard be best?
OK, I'll offer an opinion.
I agree with your "physical and psychological" threats scenario. It just makes sense that if Spidey is fighting two villains in one film, they have to have very different styles. Thus we must say NO to ideas like Venom/Lizard, Man-Wolf/Lizard, etc for obvious reasons of redundancy.
That being said, I also think that other "non-physical"-fighing villains like Electro and Hydro-Man could share a film with a monster villain, but the problem there is that their powers are quite cliche'd in the realm of SF/fantasy. I also feel the same way about Sandman, to be honest.
I'm actually OK with Lizard sharing the screen with GG2 or Hobgoblin, since those characters are more technological villans than Lizard is, so there's still a difference. Plus, there can indeed be some psychological torture or mindgames coming from Harry if he's responsible for whatever goblin villain we might see.
Plus, I've said for a long time that introducing the Maggia/Mafia-type organized crime characters like Hammerhead, Silvermane, Tombstone, etc could work well with a Lizard story much like the classic Stone Tablet storyline from ASM # 70-77.
Regarding Lizzy having his own solo movie-- that would be great and I'd love it from a fanboy standpoint. However, based on the storylines that have taken place in the past two movies, and the fact that Otto Octavius was incorrectly portrayed as a character similar to Curt Connors in SM2, I have to say that a Jekyll/Hyde scientist storyline in SM3 really needs another element thrown into the mix. Two villains is the best bet this time around.
So in a nutshell, I'm OK with:
Lizard/GG2
Lizard/Hobgoblin
Lizard/Mysterio
Lizard/Maggia characters (Tombstone, Hammerhead, etc)
Lizard/Electro (in a pinch)