What I personally would love to see is....Venom. Granted, i'm a huge Venom fan. But you have to look at this from a box office point of view. People, normal people (not us comic book geeks

), don't want to see the GG again. Harry or not, it's not good marketing stratgey. The movie would be Spidey 1 all over again. Harry gets powers, goes after Peter, then MJ, and then a big battle royal happens where he dies. Now personally, even though i'm a Spidey fan, even I don't want to see a movie about that. I'd watch it, but I probbably wouldn't enjoy it that much.
In an ideal world we get atleast 4 movies, Venom's the 3rd, closure to the Osborn/Green Goblin legacy in the 4th, and all during the 3rd they could have a small side plot about harry's growing drug/alcohal problem, leading into a completely mental breakdown for Spidey 4, where he takes on the mantle of Green Goblin (2nd) and goes after Peter. BUT you must remember Sam's made it pretty clear that Sony Pictures doesn't want more than 3, and neither does Tobey or Kirsten.
This is what I think is the best bet.....Have the movie be set a couple years after the 2nd, at the beggining have peter graduate from university (at that time he would be done his fourth year in college, give or take a few months). Then somewhere during the movie have him propose to MJ. Somewhere near the beggining they would have to introduce the symbiote, for this i'd either use the 90s Spidey animated series storyline (IE: Brought back to space by John Jameson or some other astronaut), OR they could use a similar/variation of the Ultimate Spider-Man symbiote plot. Meaning it would be an invention, possibly government created.
After you have it brought back from wherever, find some way for Peter to come into contact with it (obviously), all the while doing some subtle Brock loses career and hates Spider-Man for it plotline, possibly a variation of the comic book version. News Paper Headline: "TRUE Sin Eater Exposed...by Spider-Man!". You wouldn't actually need to show the fight between them, but it would be neat if they could fit it in. Then have Eddie walking down the dark streets at night only to find a notice saying he has to vacate his apartment psot-haste. Then entering to hear a message on the answering machine from his ex-wife talking about the divorce settlement.
Now, during the movie have Peter struggle with control of the symbiote, only to find out it's trying to take him over (most likely through angry impluses, as well as possibly yelling at Aunt May or MJ). Have some flashbacks to Peter as a child, hopefully limiting Uncle Ben's influence over the plotline (that plot is over-used). Do the whole Brock goes to chapel only to join with a rejected symbiote story. Then cut to the next scene, which occurs sometime after, with Peter and MJ moving into their new apartment (not yet married, but soon to be). Then have Venom approach MJ and scare her in her new home (like the classic spidey story), have her deathly frightened and whatnot.
Venom then plays some mind games with Peter (Threatens to reveal his identity, approaches his Aunt, etc). A huge battle occurs, Venom loses badly, but lives (or not), but if he lives that could run into the rumored "Venom" movie (where i'd like to see him battle it out with Carnage). BAM! There's 2 hours gone already. Now make the movie 2 and a half hours long and focus the last part on Harry breaking down and going after Peter, only to crash his wedding (which he had recieved an invite to). Yet another huge battle takes place, Harry (much stronger than his father, because of an enhanced formula) about to kill Peter, when suddenly his heart gives out, and he goes critical, due to the imperfect new formula, and then he dies in a hospital bed.
Okay, that's msot of another half an hour gone, and at the end show Peter and MJ (both wearing wedding rings/bands/whatever), at Harry's funeral (talking about how familiar this all seems). Now ofcourse there would be alot of other things in the movie, but that's just the basic plot. There's your movie. The perfect ending, both happy (because of the marriage) as well as sad (because of Harry unfortunate death).
The main plot would be focussed around Venom/The symbiote though, since alot of people don't want to see another movie devoted to the Green Goblin. The Lizard could make a good movie, but the plot can only be played out so long because the lizard is subject to base animal instincts, and can't really control his actions. Venom not only would make a great movie villain, but he has alot of fans, and would bring the movie a darker tone.
But hey, those are just my thoughts.
