Well, the Spectre of Spider-Man has ALWAYS come between Peter Parker and the women he loves... going all the way back to Betty Brant. He was about to tell her his identity until she got mad at Spider-Man for the death of her brother. In JQ's eyes, this is a perfect thing to happen because it just smacks of old school Stan Lee Spider-Man...
She'd be around as a good member of Spidey's supporting cast, alongside Betty Brant, Aunt May, Flash Thompson, JJJ, etc... And of course, Marvel would have plenty of stories that could last years of him pining to be with her, but he musn't touch the forbidden fruit so as to not spoil it (by exposing her to his enemies and such). He'll love her til the day he dies, but he musn't be with her because he's Spider-Man... it's his gift, it's his curse. They can weave this alongside the movies...
It's almost too glorious an opportunity for Marvel to pass up... because if done properly, we as readers will once again feel Peter's pain as Spider-Man prevents him from being with the girl he loves...