Villian 1 - Disposed of the the first couple of scenes, set a bench mark for the action early, this can also be used in the trailer to avoid spoiling nay of the story. this can be a way to introduce Eddie as a photographer and possibly get the black suit, so in 5 minutes we have made major headway.
Sandamn - brief origin in flashback dont waste time with developing him as we would with more improtant characters. he is a thug for hire possibly created by Oscorps foray into genetics. (similar to ultimate)
Harry wants Sandman to draw out spidey, sandman fails. Spidey going nuts with black suit etc. with the battle we can also have Eddie on the scene doing his thing.
GGII
Sandman fails and Harry decides to step in, possibly with help from sandman, in this scene, possibly 1hr 45 in we can have spidey dispose of sandman and get rid of the simbyote pasing to brock...
final scene, harry kidnaps MJ, Brock gets Gwen.
threeway smackdown Venom/Spidey/Goblin, get harry nocked down fairly early on then the main battle between venom and Spidey. Venom disposes of MJ (taking her out of future movies). this makes harry decide its gone to far and he helps take out venom. Peter is upset about MJ, harry leaves vowing he will have his revenge (but not yet) unconsious Brock is arrested and the movie is over, with closure but plenty of scope for sequels if needed.