No one is necessarily panicking besides a few posters here and there. For all of its faults, Apocalypse did more right than wrong I feel like - it rectified past mistakes and sets the stage well for the future. Obvious creative retooling and reassessments are necessary, but Deadpool, Wolverine III, New Mutants, X-Force gives them plenty of time to learn and find someone passionate to take on the flagship franchise.
They're in a flexible position, which is good. They just have to make the right choices here on out with the new IPs and the flagship.
Also McAvoy and Hoult wouldn't be carrying the franchise alone. Tye, Sophie, Kodi, Evan, any of them could blow up in between films like JLaw and Fassy. Tye could even be sooner with Ready Player One.