The Dark Knight is a game changer on personal level. I just can't watch any other super-hero movies anymore. The Avengers trailer makes me vomit. So did Cap. America, Green Lantern, G.I. Joe and Iron Man 2. Not sure about the new Spider-man for now. Probably, from the same league.
Batman Begins was great, but it didn't change anything. We got plenty of typical super-hero movies after that. Spider-man movies, Daredevil, Hulk movies and other. Beautiful, nice FX, but empty.
Probably, overall, the real game changer is X-Men or Spider-man. They started the decade of endless comic book movies.