It is interesting to think how much of the first 100 issues Fox can not use in making an FF movie.
Namor and the Panther are off limits - and I assume the Inhumans/Kree/Him story lines are as well. This removes about 1/5 of those issues, and some of the best story arcs.
While I do want to see Doom done right, I do not want him back in the first movie, so that removes another large number of issues.
There are some excellent Frightful Four arcs, but if Medusa and Sandman are out of the picture, are they worth it?
It will be interesting to see what they draw from...
Why should the movie be a copy and paste of the first 100 issues? Isn't there interesting stuff from other FF runs that could be used? Also movies are different from comics, so it would have been impossible to have a movie be exactly like the first 100 issues of FF. An movie adaption of a comic book should adapt the spirit of the comic, rather then trying to adapt it to the letter.
Like I have said before, many members of the Frightful Four would need a major revamp before being ready to be the main villains of a movie. Wizard is pretty lame, his original motive for being a super villain was that he was bored, that doesn't make for a villain that is sympathetic or scary or anything beyond laughable. Sure that story with Wizard using a mind control device on the Thing was fun, if when the FF confronts him and he admits that his motive for attacking them was simple boredom, that would render him rather uninteresting to audience. Now he did have that mental breakdown recently in the comics, but the writer didn't explain why Wizard had a mental breakdown and so its hard to adapt it as a motive in a movie.
Also Trapster has always been a lame villain as well. He has no motive, he could have used his paste to make a fortune legally, but he decided to rob banks instead for reasons that were never disclosed. Plus Trapster trying to attack the FF with a glue gun would be laughable, he is not a believable threat. It seems like he should be the comic relief villain who is dispatched within the first 5 minutes of the film. Trapster seems like if he brought his A game, he might be a competent street level villain, but he is not FF level threat when the FF fights Doom and Annihilus on a regular basis.
So yeah, if they do the Frightful Four, those guys need better motives and a more interesting overall plot to carry a movie, brainwashing Thing is an interesting plot point, but it doesn't make the Frightful Four interesting in of themselves.